Aperçu: G.M.
Le facteur inhibiteur de la migration des macrophages (MIF) est une cytokine.
La
MIF joue un rôle important dans la promotion des processus tumoraux,
la maladie d'Alzheimer, et est également sur-régulée dans les "troubles
du spectre de l'autisme" et la lésion de la moelle épinière, ce qui
contribue à la gravité de la zone lésée. L'effet
protecteur de la MIF a été signalé dans la sclérose latérale
amyotrophique par sa réduction de la SOD1 agrégée mal repliée , réduisant
ainsi la gravité de cette maladie. Fait
intéressant, un rôle protecteur et pathologique pour le MIF a été
impliqué dans l'accident vasculaire cérébral et l'ischémie cérébrale,
ainsi que dans la dépression. Ainsi, le rôle de la MIF dans les troubles neurologiques semble être diversifié avec des effets bénéfiques et adversaires.
Exp Neurol. 2017 Jul 2. pii: S0014-4886(17)30160-7. doi: 10.1016/j.expneurol.2017.06.021.
Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases
Author information
- 1
- Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel.
- 2
- Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel; The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel. Electronic address: adriani@bgu.ac.il.
Abstract
Macrophage
migration inhibitory factor (MIF) is a conserved cytokine found as a
homotrimer protein. It is found in a wide spectrum of cell types in the
body including neuronal and non-neuronal cells. MIF is implicated in
several biological processes; chemo-attraction, cytokine activity, and
receptor binding, among other functions. More recently, a chaperone-like
activity has been added to its repertoire. In this review, we focus on
the implication of MIF in the central nervous system and peripheries,
its role in neurological disorders, and the mechanisms by which MIF is
regulated. Numerous studies have associated MIF with various disease
settings. MIF plays an important role in advocating tumorigenic
processes, Alzheimer's disease, and is also upregulated in autism-spectrum
disorders and spinal cord injury where it contributes to the severity
of the injured area. The protective effect of MIF has been reported in
amyotrophic lateral sclerosis by its reduction of aggregated misfolded
SOD1, subsequently reducing the severity of this disease. Interestingly,
a protective as well as pathological role for MIF has been implicated
in stroke and cerebral ischemia, as well as depression. Thus, the role
of MIF in neurological disorders appears to be diverse with both
beneficial and adversary effects. Furthermore, its modulation is rather
complex and it is regulated by different proteins, either on a molecular
or protein level. This complexity might be dependent on the
pathophysiological context and/or cellular microenvironment. Hence,
further clarification of its diverse roles in neurological pathologies
is warranted to provide new mechanistic insights which may lead in the
future to the development of therapeutic strategies based on MIF, to
fight some of these neurological disorders.
Copyright © 2017. Published by Elsevier Inc.
KEYWORDS:
Central nervous system; MIF; Neurodegeneration; Neurological diseases- PMID: 28679106
- DOI: 10.1016/j.expneurol.2017.06.021
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