Aperçu: G.M.
Les
réponses auditives du tronc cérébral (ABR) peuvent être associées aux
TSA, mais les caractéristiques des participants et les protocoles
d'évaluation varient considérablement d'une étude à l'autre.
Le TSA était associé à des latences ABR plus longues pour Waves III (g = 0,5,
IC 95% 0,1, 0,9), V (g = 0,7, IC 95% 0,3, 1,1), I-III (g = 0,7, IC 95%
0,2, 1,2) et IV (g = 0,6, IC à 95% 0,2, 1,0). Tous les composants ont montré une hétérogénéité significative. Les
associations étaient les plus fortes chez les participants de moins de 8
ans et ceux sans anomalies de l'oreille moyenne ou seuils auditifs
élevés. En somme, les associations entre les ABR et les TSA sont de taille moyenne à grande, mais présentent une hétérogénéité. Toutefois,
l'identification des sources d'hétérogénéité est difficile en raison
des limitations de puissance et de la cooccurrence des caractéristiques
de l'échantillon / de la conception dans toutes les études. La
recherche portant sur les limitations ci-dessus est cruciale pour
déterminer la valeur étiologique et / ou pronostique des ABR pour le TSA.
Autism Res. 2018 Mar 30. doi: 10.1002/aur.1946.
Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review
Author information
- 1
- Department of Epidemiology & Biostatistics, Michigan State University, East Lansing, Michigan.
- 2
- Hearing Health Center, Lansing, Michigan.
- 3
- Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Abstract
Behavior
does not differentiate ASD risk prior to 12 months of age, but
biomarkers may inform risk before symptoms emerge. Click-evoked auditory
brainstem responses (ABRs) may be worth consideration due to their
measurement properties (noninvasiveness; reliability) and conceptual
features (well-characterized neural generators), but participant
characteristics and assessment protocols vary considerably across
studies. Our goal is to perform a meta-analysis of the association
between ABRs and ASD. Following an electronic database search (PubMed,
Medline, PsycInfo, PsycArticles), we included papers that were written
in English, included ASD and typically-developing (TD) groups, and
reported the information needed to calculate standardized mean
differences (Hedges's g) for at least one ABR latency component (I, III,
V, I-III, III-V, I-V). We weighted and averaged effect sizes across
conditions and subsets of participants to yield one estimate per
component per study. We then performed random-effects regressions to
generate component-specific estimates. ASD was associated with longer
ABR latencies for Waves III (g = 0.5, 95% CI 0.1, 0.9), V (g = 0.7, 95%
CI 0.3, 1.1), I-III (g = 0.7, 95% CI 0.2, 1.2), and I-V (g = 0.6, 95% CI
0.2, 1.0). All components showed significant heterogeneity.
Associations were strongest among participants ≤8 years of age and those
without middle ear abnormalities or elevated auditory thresholds. In
sum, associations between ABRs and ASD are medium-to-large in size, but
exhibit heterogeneity. Identifying sources of heterogeneity is
challenging, however, due to power limitations and co-occurrence of
sample/design characteristics across studies. Research addressing the
above limitations is crucial to determining the etiologic and/or
prognostic value of ABRs for ASD. Autism Res 2018. © 2018 International
Society for Autism Research, Wiley Periodicals, Inc.
LAY SUMMARY:
Auditory brainstem responses (ABR) may be associated with ASD, but participant characteristics and assessment protocols vary considerably across individual studies. Our goal is to combine the results across these studies to facilitate clarity on the topic. Doing so represents a first step in evaluating whether ABRs yield potential for informing the etiology of ASD risk and/or ASD symptom profiles.
© 2018 International Society for Autism Research, Wiley Periodicals, Inc.
- PMID:29603654
- DOI:10.1002/aur.1946
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